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Source: Chemical EngineeringView original →
TechnologyApril 3, 2026

Use this ultrasonic flowmeter in low-flow bioprocessing operations

Summary

SONOFLOW CO.55 SD V3.0 is a non-contact ultrasonic flowmeter from SONOTEC designed for single-use bioprocessing applications, with particular emphasis on low-flow process development and fill-and-finish operations. The instrument features a touchscreen interface for real-time flow monitoring and on-the-spot parameter adjustment without process interruption. The V3.0 series targets pharmaceutical and biotech manufacturers running disposable fluid path systems where contamination risk from wetted sensors is a concern.

Why It Matters

In biopharmaceutical manufacturing, accurate low-flow measurement has historically been a pain point -- traditional Coriolis or differential pressure instruments lose accuracy and repeatability at the flow rates common in process development and small-batch fill-and-finish. A non-contact ultrasonic approach on single-use tubing eliminates the cross-contamination risk inherent to reusable wetted sensors while also reducing cleaning validation burden, which is a meaningful labor and compliance cost in regulated environments. The on-device parameter adjustment reduces dependence on control room personnel for routine calibration touchpoints, potentially compressing changeover time between batches. For manufacturers scaling up biologics or cell and gene therapy products -- where batch sizes are small but per-unit value is high -- tighter flow measurement at this range directly supports yield protection and process consistency documentation required by FDA and EMA process analytical technology frameworks.